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Kaffe Bueno Unveils New Clinical Results for Patented KAFFAGE® Technology: Proven Skin Transformation in 28 Days


Wrinkle depth before and after using KAFFAGE pictures
Macroscopic Pictures of crow’s feet wrinkles showing depth changes from Day 0 to Day 28 after treatment.

Copenhagen, October 2025


Kaffe Bueno, the Danish bioscience company redefining coffee’s purpose, has released new in vivo clinical data confirming the strong efficacy of its patented ingredient, KAFFAGE®.

KAFFAGE® is a multifunctional active biopolymer for applications in skin care, make up and sun care.


As the first and only company to fully upcycle coffee by-products after inaugurating the world’s first coffee biorefinery in 2023, Kaffe Bueno continues to lead innovation in sustainable personal care by demonstrating clinically proven efficacy for upcycled and natural ingredients.


KAFFAGE®, KAFFAGE-B®, KAFFAGE-D®, and KAFFAGE-BD® — upcycled coffee-based ingredients for sustainable skincare.
The versions of KAFFAGE®

The newly released clinical study reinforces the multifunctional benefits of two versions of KAFFAGE®; KAFFAGE-D® and KAFFAGE-BD®, two ingredient formats developed through Kaffe Bueno’s proprietary extraction process.


KAFFAGE-D® is the Dispersion of KAFFAGE®, while KAFFAGE-BD is the Dispersion of KAFFAGE-B®.







The study reveals a statistically significant improvement in skin hydration, firmness, elasticity, and reduces wrinkle depth in just 14-28 days, for volunteers who used the test products containing KAFFAGE®.




KAFFAGE® Improves and Sustains Skin Hydration


In a 28-day clinical study involving 60 women, two KAFFAGE® variants, KAFFAGE-D® and KAFFAGE-BD®, were tested in facial serums against a placebo. The results speak volumes:


Bar chart showing KAFFAGE-D® significantly boosts skin hydration vs placebo after 14 and 28 days; KAFFAGE-BD® also improves hydration at 28 days.
Skin hydration changes from Day 0 to Day 14 and Day 0 to Day 28 after treatment with PLACEBO, KAFFAGE-D®, and KAFFAGE-BD®.

Hydration

KAFFAGE-D® increased skin hydration by +29.6% after 14 days, 174% higher than placebo.


KAFFAGE-BD® also delivered a  +15.5% hydration increase after 28 days. Both maintained moisturisation for up to 10 hours, with KAFFAGE-D® extending effects up to 48 hours after final use.







KAFFAGE® Improves and Maintains Skin Firmness and Elasticity


Bar chart showing KAFFAGE-BD® improved skin firmness by 15.1% after 28 days, outperforming KAFFAGE-D® (12.2%) and placebo (8.2%).
Skin firmness changes from Day 0 to Day 28 after treatment.

Firmness


KAFFAGE-BD® improved skin firmness by +15.1%, while KAFFAGE-D® achieved a +12.2% increase after 28 days, as measured using a Cutometer.











Bar chart showing KAFFAGE-D® improved skin elasticity by 13.3% and KAFFAGE-BD® by 8.2% after 28 days, compared to a -5.7% drop with placebo.
Skin elasticity changes from Day 0 to Day 28 after treatment.

Elasticity


Compared to a -5.7% decrease in the placebo group, KAFFAGE-D® increased skin elasticity by +13.3%, and KAFFAGE-BD® by +8.2%, corresponding to a 333% and 244% improvement over placebo, respectively.













KAFFAGE® Reduces Wrinkle Depth


Crow’s Feet Wrinkle Depth


Using VISIA-CR imaging, KAFFAGE-D® demonstrated a 12.0% reduction in crow’s feet wrinkle depth after 28 days. Macroscopic photography confirmed visible improvements in skin texture and smoothness.


Bar chart showing KAFFAGE-D® reduced crow’s feet wrinkle depth by 12% after 28 days, outperforming KAFFAGE-BD® and placebo.
Crow’s feet wrinkles depth changes from Day 0 to Day 14 and Day 0 to Day 28 after treatment.

Close-up photos of a volunteer's eye area before (D0) and after 28 days (D28), showing visible wrinkle reduction.
Macroscopic Pictures of crow’s feet wrinkles showing depth changes from Day 0 to Day 28 after treatment.

Consumer Perception 


After 28 days of use, participants using KAFFAGE-D® or KAFFAGE-BD® serums said their skin felt softer and more hydrated. 

  • 95% reported improved skin suppleness 

  • 95% saw smoother facial contours 

  • 90% noticed more even tone and enhanced skin quality 

  • 85–95% reported their skin looked firmer and younger 




The First of Its Kind. Patented. Proven. Pioneering.


“It’s not just an ingredient. It’s a movement. KAFFAGE® is a testament of the powerful compounds in nature that are naturally hued. Chemically, it is what gives coffee its characteristic colour. We isolate this compound and separate it by molecular weight for hyper-targeted benefits. Kaffe Bueno is the first and only company who has ever isolated this compound industrially and used it in this way. It is no longer coffee. It is water soluble. It is patented. It is multifunctional. It protects skin at a cellular level while reversing signs of ageing. It serves as a SPF Booster (data coming soon). It is not white. It will make your formulations look attractively natural, without staining the skin while delivering clinically proven benefits” said Alejandro Franco, Co-Founder and Co-CEO at Kaffe Bueno.

KAFFAGE® and its variants, KAFFAGE-D® and KAFFAGE-BD®, deliver real performance and a natural aesthetic through their warm-toned colour, water solubility and oil dispersibility, and formulation versatility. They are NATRUE and Ecocert Cosmos - approved, China Compliant, dermatologically tested, and suitable for a wide range of skincare, body care, and hybrid makeup applications.




About Kaffe Bueno


Kaffe Bueno is a Danish bioscience company dedicated to upcycling coffee by-products into functional ingredients for cosmetics, nutraceuticals, and functional foods. Committed to sustainability and innovation, Kaffe Bueno’s mission is to unlock the full health potential of coffee while contributing to a circular, zero-waste economy.


For press enquiries, please contact:


Noomi Mikkelsen

Marketing & Branding Coordinator

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